To The Results of Experimental Mycological Studies of Activated Silica Water in Relation to Strains of C. Albicans.

Abstract

The article presents experimental miclogical studies of the determination of the antimicotic efficacy of activated silicon water. The experimental mycological studies to determine the antimycotic properties of activated siliceous waters showed that disks impregnated with activated siliceous waters with SiO₂ content at a dose of 48.2 mg/l increase the sensitivity of C. albicans to antimycotics by 1.4 times, and at a SiO₂ concentration of 20 mg/l - 1.2 times, respectively. The results obtained are of great importance in the development of effective methods of antimycotic therapy.

Recently, the geological services have been actively discussing the development of a new direction in geology, called medical geology. [2,10]. In the Republic of Uzbekistan, this has already originated in the use of natural waters for medicinal purposes. [2] When solving practical problems, the main emphasis is on natural mineral waters (questions of studying their distribution and medicinal properties, calculating reserves, etc.).

The global market is characterized by a tendency to consume drugs of natural origin used for the prevention and treatment of diseases of various etiologies. This is an aqueous solution of silicon water. [1, 4,7]

Mineral waters containing silicic acid have long attracted the attention of balneologists. They are used in the treatment of skin diseases, traumatic injuries, diseases of the gastrointestinal tract (with the content of silicic acid, mainly in undissociated, colloidal form, in particular in skin diseases). Silicon waters are also used for metabolic disorders in the body, diseases of the biliary tract, organs of support and movement, and the nervous system.

For example, Tashkent mineral water, containing silicic acid up to 40 mg/l or more, having a bacteriostatic and bactericidal effect on conditionally pathogenic microorganisms, is widely used for balneotherapy in the treatment of a number of diseases in the health resorts of Tashkent and the Tashkent region. [2]

Silicic acid in an amount of more than 50 mg/l is typical for most nitrogenous thermal waters with a temperature of more than 35° C. Its content in groundwater usually depends on temperature and pressure. Scientific research of recent years has shown that the intensive exploitation of underground mineral waters, along with a negative impact (a decrease in pressure affects the decrease in total reserves), also has a certain positive effect on the change in the chemical composition of mineral waters.[2,4,7]

In medical practice, the determination of the sensitivity of microorganisms - the causative agents of human infectious diseases to antibacterial drugs (ABP) - is becoming increasingly important due to the emergence and widespread antibiotic resistance in bacteria. Studies have shown that the resistance of microorganisms to antibiotics can be natural and acquired [3,5]. Natural resistance is a constant species feature of microorganisms [3]. True natural resistance is characterized by the absence of an antibiotic target in microorganisms or the inaccessibility of the target due to initially low permeability or enzymatic inactivation [1].

The aim of the study was to study the antimycotic activity of silica water against clinical strains of C.albicans.

Material and research methods. The experimental study was carried out on 15 strains of C.albicans isolated from patients with skin diseases in the bacteriological laboratory of the RSSPMCDVNandC of the Ministry of Health of the Republic of Uzbekistan. The antimycotic activity of activated siliceous water provided by SE GIDROYENGEO was studied. The disk-diffusion method was used to study the antimycotic activity of activated siliceous waters. Were used sterilized activated siliceous water containing silicon oxide - in a dose of SiO₂ - 20 mg/l and 48.2 mg/l.